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Taiwan military officials confirmed that Taiwan Province wants to buy the "strongest tank on the surface" from the United States.

 CCTV News:A few days ago, the news that the Taiwan military will buy M1A2 tanks from the United States, which is known as the "strongest chariot on the surface", has aroused concern from all walks of life on the island. Some experts believe that the political significance of purchasing tanks is far greater than the military significance. Then, US arms sales to Taiwan are not good for cross-strait relations and Sino-US relations. Why does Taiwan Province insist on buying from the US military? What impact will this have on the situation in the Taiwan Strait?

  [News background]

 

  Taiwan Province’s China Times reported that Taiwan’s military officials confirmed that Taiwan’s defense agencies will formally budget about NT$ 30 billion next year and purchase about 100 M1A2 tanks from the United States, which Tsai Ing-Wen is quite supportive of. M1A2 tank is called "the strongest chariot on the surface" and weighs about 70 tons, which is 20 tons heavier than the active "Brave Tiger" tank of Taiwan Army. The head of Taiwan Province’s defense department said that this tank will be the key force for the Taiwan military to "win the battle on the seashore and wipe out the enemy". Holding a tank that can block the armored spearhead of the People’s Liberation Army will not only boost the morale of officers and men, but also provide the people in Taiwan Province with a certain degree of psychological guarantee of "promising resistance". However, some experts said that Taiwan Province’s purchase of tanks is more about paying protection fees to the United States, and its political significance is greater than its military significance. For the so-called "defending Taiwan Province against reunification", it will not play much role.

  Taiwan Province wants to buy the "strongest surface" tank from the United States.

 Image source network

Image source network: Professor Qiu Yi of China Culture University

  Qiu Yi, a professor at China Culture University.M1A2 tank has a brand-new and most advanced battlefield management system and an inter-vehicle information system. It is equipped with brand-new defense armor and electronic equipment, so it is called the strongest digital tank in active service of the US military. Taiwan Province used to want to buy this type of tank, but the United States thinks that this type of tank can’t be maneuvered at all on terrain like Taiwan Province. Now Tsai Ing-Wen relies heavily on Yan Defa, the head of Taiwan Province’s defense department. He is an armored soldier, and now he wants to restart the stove and ask the United States. This time, the United States tends to agree. Recently, relevant reports from the CIA in Sweden and the United States mentioned some weaknesses of M1A2 tanks, and even mentioned that the mainland 99A main battle tank, which followed closely, could penetrate the protective armor of M1A2 tanks after firing armor-piercing projectiles. It shows that it is not as strong as it is boasted at present. More importantly, M1A2 tanks are mainly used in the Gulf campaign, which is suitable for large-scale grassland or desert operations. The terrain of Taiwan Province makes M1A2 tanks useless, and even becomes a fixed battery and becomes the target of the other side because of inconvenient movement. "

  No matter whether it is suitable or not, the Taiwan Province authorities have compiled a budget. How long will it take from the budget estimation to the successful purchase from the United States and the transportation of tanks to Taiwan Province to equip the Taiwan military to form a combat force? Even if these tanks are really equipped inside the Taiwan military, how big is the improvement of combat power? In particular, how much can land defense help?

 

  Yu Qiang, Associate Professor, School of International Relations: "In terms of time, if the budget is prepared now, it should be paid to the US from 2019. Americans will definitely not see rabbits and not scatter eagles. The question is when the US will hand over tanks to Taiwan Province, depending on what tanks the US will give to Taiwan Province. If the US gives Taiwan Province refurbished old tanks, the delivery speed will be faster. If it is newly built by the US, will the US agree that if it takes a very long time to build, tanks equipped to the Taiwan military will enhance their combat effectiveness? Because, Taiwan’s active tanks are too old, a CM11‘ Yonghu ’ The type tank equipped in 1990 has been ‘ 28 years old ’ . Another M60A3 tank was equipped in 1995. This tank was retired after the Gulf War in the United States. It was sold to Taiwan Province after being refurbished, and its service life has been ‘ More than 30 years old ’ Yes. In 2016, a tank of the Taiwan Province military fell into the river when crossing the bridge, and three soldiers were killed. "

  Even if it is bought back, it may not work. Even if it can satisfy Tsai Ing-Wen’s vanity, why does she insist on buying it? Some commentators believe that this is actually the opportunity for Tsai Ing-Wen authorities to pay protection fees to the United States to seek help and support from the United States. Can American military equipment really protect the safety of Taiwan Province people?

  Qiu Yi, a professor at China Culture University.Many people and opponents in Taiwan Province believe that Taiwan Province is in a difficult financial situation and is heavily in debt, so the money should be used where it should be. Tsai Ing-Wen authorities don’t think so. Cai authorities have to rely on the so-called strengthening of US-Taiwan relations to decorate the facade to boost the support rate. The United States knows Taiwan Province’s mentality, so it can blackmail as much as it can. When something happens in Taiwan Province, 100% of the United States will not help defend Taiwan Province, and the United States just pays lip service to it. The United States regards Taiwan Province as a big head, as a chip and pawn that can be discarded at any time, and as a pawn and watchdog of others. Tsai Ing-Wen wants to resist reunification and go ‘ Taiwan independence ’ The route is still determined to go to this dead end. "

  Whether Tsai Ing-Wen buys tanks or other weapons and equipment from the United States, it is futile to refuse reunification by force. Moreover, the more such protection fees are paid, it will not only aggravate the tension between the two sides of the strait, but also arouse the dissatisfaction of the people on the island.

Strictly check the online performance and online game market! Fourteen companies were blacklisted.

  CCTV News:Recently, the Ministry of Culture and Tourism once again organized a centralized law enforcement inspection of online performances and online game markets. The communication channels of mobile performance platforms, prohibited contents of online performances and prohibited contents of online game markets are the focus of this centralized inspection.

  In the special clean-up of mobile phone performance platforms in major Internet application stores such as Tencent, Baidu, Ali, 360, Huawei, Xiaomi, Lenovo, OPPO and VIVO, the Ministry of Culture and Tourism investigated 4,939 live mobile phone applications, among which 370 offline mobile phone performance platforms were deleted. Beijing Miko World Technology Co., Ltd., Shanghai Duluo Information Technology Co., Ltd., Chenyu Technology (Fujian) Co., Ltd., Guangzhou Yicheng Information Technology Co., Ltd., etc.Fourteen units were blacklisted by the Ministry of Culture and Tourism for forging business licenses for online culture.57 mobile phone performance platforms and other applications they provided were offline, and industry-wide credit punishment was implemented, and relevant clues were transferred to relevant departments for legal treatment.

  According to complaints from the masses, the Ministry of Culture and Tourism organized centralized law enforcement inspections on 30 online performance platforms, including Zanthoxylum bungeanum Live, Six Rooms Live, Panda Live, DouYu Live and Tiger Tooth Live. At present, 190 prohibited content problems such as endangering social morality and promoting violence have been identified, involving 110 live rooms, and follow-up inspections and investigations are being carried out.

  50 online games such as "Chu Liuxiang" and "Love and Producer" are the focus of investigation.

  The focus of the centralized investigation of the online game market includes providing prohibited content such as obscenity and pornography, endangering social morality, promoting violence, gambling, instigating crimes, etc., and inducing users to obtain online game products and services by means of random sampling.The Ministry of Culture and Tourism has organized law enforcement officers to conduct centralized investigation and clean-up of 50 online game products such as "Chu Liuxiang" and "Love and Producer".

  Today, the Ministry of Culture and Tourism also announced the telephone number (010-59881010) and the reporting platform (www.12318.gov.cn) for centralized law enforcement inspection in the online cultural market, and welcomed the public to report and supervise illegal online performances and online game business activities.

  1. Pepper live broadcast; 2. Six rooms; 3. honey crazy live broadcast; 4. Live broadcast of red people; 5. Panda live broadcast; 6. What a live broadcast; 7. Chatting; 8. Hualang live broadcast; 9. Warm live broadcast; 10. Dragon Ball live broadcast; 11. Live broadcast of the battle flag; 12. Have fun live broadcast; 13. Live broadcast in Gentle Township; 14. Miaobo; 15. Sina SHOW; 16. Assembly entertainment; 17. Live broadcast; 18. Hot dance live broadcast; 19. Tianxiang live broadcast; DouYu; 21. Live night train; 22. Yutu live broadcast; 23. Tiger tooth live broadcast; 24. Netease CC live broadcast; 25. Peach live broadcast; 26. Live by moonlight; 27. Live broadcast of tadpole nest; 28.17 Play live; 29. What a live broadcast; 30. Night Show Live Room.

  Centralized inspection of 50 online game products

  1. Let go of those three countries; 2. War and order; 3. The age of musket; 4. the sky front; 5. Plague Company; 6. World War II; 7. Douro Continent 3; 8. Creation and magic; 9. The football of the giants; 10. make a demon plan; 11. the contract of food; 12. Wang Ye is not good; 13. Sword and Home; 14. The road to a strong nautical king; 15. Life and death fighting 5 infinite; 16. Nautical King sets sail; 17. Glory of the Republic 2; 18. Ji Mo loves war discipline; 19. My mission; 20. the era of angels; Angel sword; 22. Ghost Story; Terminator 2: Judgment Day; 24. Rebellious Million King Arthur; 25. decisive battle! Ping an Jing; 26. Soul hunting awakens; 27. The eternal city of seven days; 28. The fifth personality; Chu Liuxiang; 30. Wilderness Action; 31. Love and producer; 32. Magic Pocket Edition; 33. call me long live ye; 34. Friends, please stay; 35. the era of Cang; SHEN WOO 3; 37.QQ dazzles dance; 38. Miracle: Awakening; 39. Crossing the line of fire; 40.QQ Huaxia; 41. Naruto; 42. The new knight errant love; 43. choosing a day; 44. Xuanyuan legend; 45. the royal dragon is in the sky; 46. Journey; 47. Dragon Ball atrix; 48. The ultimate battle of the king of fighters 98 OL; 49. Fairy Tale; 50. Starship Empire.

  List of units that forge online documents:

  1. Beijing Miko World Technology Co., Ltd.;

  2. Jilin Jiaan Network Information Technology Co., Ltd.;

  3. Shanghai Duluo Information Technology Co., Ltd;

  4. Shanghai Netcast Information Technology Co., Ltd.;

  5. Chenyu Technology (Fujian) Co., Ltd.;

  6. Hangzhou Haixi Network Technology Co., Ltd.;

  7. Hangzhou Maimai Network Technology Co., Ltd.;

  8. Hangzhou Soumi Network Technology Co., Ltd.;

  9. Hangzhou Xiakexing Network Technology Co., Ltd.;

  10. Hangzhou Youtong Network Technology Co., Ltd;

  11. Guangzhou Yicheng Information Technology Co., Ltd.;

  12. Shenzhen Activist Network Technology Co., Ltd.;

  13. Shenzhen Yike Technology Co., Ltd.;

  14. Ningxia Youha Network Technology Co., Ltd..

Revealing the movie key extension: play a key role or icing on the cake?


Special feature of 1905 film network Not long ago, the film announced the second key extension, which triggered a hot discussion among netizens about the key extension of the film. Key extension is a way for film copyright owners to extend the validity of electronic keys, thus extending the film release time.

Looking at the domestic films with key extension, from the early days, only a few films choose to postpone the key every year, and now more than a dozen domestic films are postponed for screening every year. What are the doorways behind the doubling of the number of key extension films?



The earliest key extension in China can be traced back to "Crazy Stone" in 2006. A small-budget film can reach that box office at that time, which makes the whole market very excited. At that time in 2015, although the box office had reached a relatively high level, there were such strong imported blockbusters in the same year. monster hunt chose the key extension method and finally became the box office champion in that year.

In recent years, more and more movies have chosen to postpone their keys. In 2019, nearly 20 movies chose to postpone their keys. Nowadays, the key extension has become a hot search word in major schedules. For these movies, the key extension can increase the exposure and bring certain box office income.



The success of "monster hunt" is not a special case. At present, the top ten domestic movies in China have been extended with keys. Does this mean that key extension plays a decisive role in the box office?

Wu Yanyu, a film critic, said: "The decisive role is definitely not played, but for some films, there will still be a longer release cycle. For example, in The Battle at Lake Changjin, the word-of-mouth of the film continues to ferment after the National Day file, and even the box office grows very fast on weekdays, indicating that a large number of viewers know about the film’s release, but they haven’t had time to see it yet. At that time, the key extension time was quite long. The data showed that the final key extension time brought more than 300 million box office to Wolf Warriors 2, which still accounted for a certain proportion of the total box office of more than 5 billion. "



Interestingly, all the top ten domestic movies in China have been extended with keys, but this does not mean that the key extension is the decisive factor for them to become the top ten box office in film history, because these movies have their own basic discs at the box office, which makes the key extension play a role of extra points. When most filmmakers decide whether to extend the key, they will make a calculation of the box office trend. If the box office of the film is already in a relatively downward or even basically no state, there is no need to extend the key for this film.



Nevertheless, many filmmakers have made efforts and attempts. For example, this year’s very high-quality domestic animated film "Dick Pig" has been extended, and some other literary films have also made the same choice.

Wu Yanyu said: "According to the current data, the key extension obviously did not play a role in promoting the box office. On the other hand, if the cinema release time is extended, it means that the window period of streaming media on the film will be longer and the distribution cost of getting new media will be relatively reduced. According to different films, some art films may be released for a short time, and the audience’s word of mouth has not sunk into the audience that should be there. At this time, if you judge that there is still a chance to take a shot and try. "



The program interviewed the cinema manager and asked them about the key extension. Ou Bowen, general manager of Perfect World Co., Ltd. mentioned: "In theory, basically all movies can extend the key, but I personally think this is only suitable for high-quality movies. For example, The Battle at Lake Changjin’s key extension in the past two months is really a stimulus to the film market, which has been greatly improved. The current movie cycle should be week by week, and new movies are released every Monday to Friday. The release of new films will squeeze into the film arrangement space of old films. Unless the schedule environment has certain particularity, it is possible that after the film is postponed, there is still no good film to compete, and the postponed film itself is very high-quality. It is possible to achieve an ideal film arrangement effect, but the probability of this happening is not great. "



It can be seen from all aspects that the extension of the key has no direct impact on the film’s arrangement and box office. Usually, the news of the extension of the key released by the film side is often a statement picture, which is often ignored by many viewers, which also leads to the limited effect of the extension on many films. How to make better use of key extension and maximize its value?

Wu Yanyu mentioned: "In the second and third months, the film should reach the audience who are particularly sinking, and stimulate those who don’t walk into the cinema every day, but are willing to support domestic films if they see something they like. This is a long-term proposition, which may be particularly applicable to films that choose a key extension."



As a means, key extension is only icing on the cake after all. To win the audience and box office, the most important thing is the quality of the film itself. Whether it can stimulate the audience, stimulate their empathy and make the audience feel that it is the right thing to go into the cinema to support the film, which is the root of the film becoming an explosion. It takes hard work to strike while the iron is hot. May the creators polish their works and win by quality.


Notice of Beijing Municipal Bureau of Civil Affairs, Beijing Municipal Bureau of Finance, Beijing Municipal Bureau of Human Resources and Social Security, Beijing Municipal Health and Wellness Committ

Jingmin Pension Fa [2019] No.160

District Civil Affairs Bureau, Finance Bureau, Human Resources and Social Security Bureau, Health and Wellness Committee, Veterans Affairs Bureau, Medical Insurance Bureau and Disabled Persons’ Federation:

  The measures for the implementation of subsidies for the elderly in Beijing are hereby printed and distributed to you, please implement them carefully.

Beijing Municipal Civil Affairs Bureau

beijing finance bureau

Beijing Municipal Bureau of Human Resources and Social Security

Beijing Municipal Health and Wellness Committee

Beijing retired military affairs bureau

Beijing Municipal Medical Security Bureau

Beijing Disabled Persons’ Federation

September 30, 2019

Measures for the implementation of Beijing Municipality on the administration of subsidies for the aged care services

  According to the Opinions of the General Office of the State Council on Promoting the Development of Aged Care Services (Guo Ban Fa [2019] No.5), the Notice on Printing and Distributing the Plan for Promoting Equalization of Basic Public Services in the Thirteenth Five-Year Plan (Guo Fa [2017] No.9) and the Opinions on Formulating and Implementing Care Services for the Elderly (Guo Ban Fa [2017] No.52), And the spirit of laws, regulations and policy documents such as the Notice of the Ministry of Finance, the Ministry of Civil Affairs, and the National Office for Ageing on Establishing and Perfecting the Subsidy System for the Elderly with Financial Difficulties (Caishe [2014] No.113), the Regulations on Home Care Services in Beijing, and the Implementation Opinions on Strengthening Care Services for the Elderly and Perfecting the Pension System (Beijing Zhengban Fa [2018] No.41), to improve the subsidy system for the elderly.

  I. General requirements

  (A) the guiding ideology

  Guided by Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era, we will firmly establish the people-centered development concept, adhere to the concept of innovation, coordination, green, openness and shared development, take the needs of the elderly as the guide, aim at promoting the construction of the old-age service system in the first good area and improving the care service level for the elderly, ensure the basic old-age service needs of the elderly, and promote the resolution of the contradiction between the people’s growing needs for a better life and the unbalanced development, so that the elderly can have a sense of gain, happiness and security.

  (II) Objectives and tasks

  1 efforts to achieve the goal of elderly care services. Focusing on the implementation of the Party Central Committee’s requirements for strengthening elderly care services and the State Council’s regulations on comprehensively establishing a subsidy system for the economically disadvantaged, elderly and disabled elderly, we will deepen and refine specific policy measures and continuously improve the level of home care services for the elderly.

  2. Effectively alleviate the difficulties of life care for the elderly. Through policy creation, integration and convergence, we will help the elderly and their families with financial difficulties, disability and advanced age to improve their consumption and payment ability, promote the enjoyment of professional, professional and diversified care services, and effectively reduce the burden of home-based care.

  3. Promote the formation of a diversified capital investment pattern. Guided by the demand and effective supply of the elderly, we will give play to the guidance and demonstration effect of financial funds, adjust and change the way of government service supply, further establish and improve the subsidy system for old-age services that is tilted towards the economically disadvantaged, disabled and elderly, and deepen the construction of the old-age service system in this city.

  4. Better reflect the concept of fair and sustainable development. Strengthen the structural reform of the supply side of old-age care services, promote the docking of professional service supply and realistic and effective demand, provide stable guarantee through the scientific subsidy system for old-age care services, realize the fairness and efficiency balance of public financial investment, and make subsidies more targeted and effective.

  5. Promote the equalization of basic old-age public services. We will build a subsidy system for the elderly with wide coverage, rich connotation and close connection, effectively connect with the living allowance for the disabled with difficulties and the nursing allowance system for the severely disabled, and smoothly connect with the long-term care insurance system that is being piloted, so as to promote the continuous improvement of the security level of the old-age service and promote the equalization of basic old-age services.

  Second, the scope, object and standard of subsidies

  Subsidies for old-age care services for the elderly are paid to the elderly who have registered in this city and meet the corresponding conditions, including subsidies for old-age care for the elderly with difficulties, subsidies for nursing for the disabled elderly, and subsidies for the elderly.

  The specific subsidy targets, scope of use and standards are as follows:

  (1) Subsidies for old-age care services for the needy elderly. It is distributed to elderly people with difficulties such as low-income and family planning families, and is used for daily care and other living service subsidies.

  1. The elderly who enjoy the subsistence allowance (including those who receive subsidies for the living difficulties of urban residents in Beijing, the same below) are entitled to 300 yuan per person per month.

  2 low-income families do not enjoy the treatment of the elderly, the subsidy standard is 200 yuan per person per month.

  3. For the elderly who belong to the family planning special families in this city and do not meet the conditions in the preceding paragraph 1.2, the subsidy standard is 100 yuan per person per month.

  (2) Nursing subsidies for the disabled elderly. It is paid to the elderly who are severely disabled or have corresponding disability certificates for long-term care subsidies caused by lack of self-care ability, including but not limited to purchasing care services such as care support, care services and nursing services. The pilot area of long-term care insurance should do a good job in coordinating the nursing subsidy for the disabled elderly and the long-term care insurance service mechanism, so that professional nursing services can better benefit the disabled elderly and their families. All districts should speed up the improvement of the old-age service system, debit the nursing subsidies to the accounts of the elderly, use the service payment method to care for the consumption within the service scope, and allow it to be used for the purchase of nursing supplies and other consumption expenses, so as to ensure that the service needs of the elderly with multiple personalities, convenient payment and professional care can be effectively met. In principle, the accounts do not support cash withdrawal, irregular clearing, and no limited regional consumption within the administrative area of Beijing, and the exceptions in the implementation will be notified separately.

  1. The elderly who are severely disabled by comprehensive assessment of their abilities, the elderly with visual, physical, intellectual and mental disabilities with disability grade I, and the elderly with multiple disabilities with intellectual and mental disabilities with disability grade II, the subsidy standard is 600 yuan per person per month.

  2. For the elderly with visual and physical disabilities with disability grade II, and the elderly with intellectual and mental disabilities with disability grade II and III, the subsidy standard is 400 yuan per person per month.

  3. The subsidy standard for the elderly with hearing and speech disabilities with disability grade I and II is 200 yuan per person per month.

  (3) allowance for the elderly. It is distributed to the elderly aged 80 and above for the consumption of old-age services, especially life care and nursing services.

  1.80 to 89 years old, the allowance standard is 100 yuan per person per month;

  2.90 to 99 years old, the allowance standard is 500 yuan per person per month;

  3.100 years old and above, the allowance standard is 800 yuan per person per month.

  Third, policy convergence

  1. Eligible elderly people can apply for pension service subsidies for the elderly with difficulties, nursing subsidies for the disabled elderly and allowances for the elderly.

  2. After the implementation of these measures, the subsidy system for the disabled at home for the severely disabled aged 60 to 79, the subsidy system for the elderly aged 80 and above, the old-age allowance system for the elderly aged 90 and above, and the subsidized medical care system for the elderly aged 95 and above in this city will cease to be implemented.

  3. The old-age service subsidies and nursing subsidies for the disabled elderly stipulated in the present Measures and the living subsidies and nursing subsidies stipulated in the Measures for the Implementation of Living Subsidies for the Disabled and Nursing Subsidies for the Severe Disabled in Beijing are not enjoyed repeatedly, and eligible elderly people can apply for one of them independently.

  4. Older people who meet the conditions of pension service subsidies for the elderly with difficulties and nursing subsidies for disabled elderly people, as well as welfare life subsidies (allowances) and nursing subsidies (allowances) such as disability and retirement on business can choose to apply for one of the service subsidies, living subsidies (allowances) and nursing subsidies (allowances).

  5. The elderly who enjoy the nursing subsidy for the disabled and the nursing fee for the educated youth who are disabled on duty do not enjoy the nursing subsidy for the disabled elderly, but can enjoy the subsidy for the aged care service for the elderly with difficulties. The elderly who enjoy the "Implementation Measures of Beijing Municipality on Subsidies for Social Welfare Institutions for Difficult Family Service Clients" do not enjoy the nursing subsidies for the disabled elderly. Those who meet the conditions may apply for subsidies for the elderly with difficulties.

  6. The elderly who receive work-related injury insurance and living care fees and are included in the support guarantee for the destitute do not enjoy the subsidy for the aged care service for the elderly with difficulties and the nursing subsidy for the disabled elderly.

  7 the provisions of this approach for the elderly pension service subsidies are not included in the urban and rural minimum living security family income.

  8. Relevant policies such as home care service and capacity assessment that have been formulated and implemented in each district, as well as the districts that have introduced the pilot scheme of long-term care insurance, shall be properly connected, gradually integrated and implemented as a whole according to the provisions of these Measures.

  9. The assessment mechanism and criteria for disability of the elderly involved in these Measures shall be implemented in accordance with the Implementation Measures for Comprehensive Assessment of the Ability of the Elderly in Beijing (Trial) (J.M.G.F. [2019] No.42).

  Iv. application procedures

  Adhere to the "efficiency orientation", promote the reform of service methods and optimize the service environment, so that data can run more and people can run less errands, "run at most once" and "only enter one door".

  (1) The elderly who meet the application conditions or their entrusted agents or guardians apply voluntarily. Applicants can log on to the Beijing Municipal Affairs Service Network, the official website of Beijing Civil Affairs Bureau or WeChat WeChat official account through smart phones, computers and other devices, enter their names and ID numbers and fill in the application; You can apply at the nearest service window of any street (township) in this city by presenting the original identity card or residence booklet; You can collect and fill in the Application Form for Allowance for Old-age Services in Beijing in the community (village) or street (township), and then submit it to the street (township) where the household registration is located for social assistance or the "one-door acceptance" window.

  For the convenience of applicants, for those who have not applied before October 25, 2019, the Beijing Social Welfare Integrated Management Platform (hereinafter referred to as the "Integrated Management Platform") will push the notice of granting subsidies for old-age services through the mobile phone numbers reserved by the elderly, and after confirming the reply, the integrated management platform will directly generate and distribute subsidies to the bank accounts held by the elderly.

  (two) the elderly who apply for disability care subsidies need to conduct a comprehensive assessment of the ability of the elderly. Among them, the elderly who are rated as severely disabled, the comprehensive management platform automatically generates and issues nursing subsidies.

  (3) All districts will comprehensively promote the whole process of online handling through the comprehensive management platform, and the whole city will dock the national unified information management system for aged care services through the comprehensive management platform. The basic information and electronic certificates of the elderly with minimum living allowance, low income, disability and family planning special families and those who have applied for and received comprehensive assessment of their abilities will be authenticated through the sharing of government information systems such as the comprehensive management platform, simplifying the acceptance and approval procedures and promoting paperless office. Support qualified areas to establish paperless application and follow-up audit procedures, and the materials to be handled shall be subject to online electronic files. The city’s application information is automatically assigned to the application window of the street (township) where the applicant’s household registration is located by the comprehensive management platform. The detailed policy implementation measures in each district should be disclosed to the public in a timely manner and let the elderly and their families know.

  (four) if the application conditions of the elderly who have enjoyed the old-age service subsidy change, the comprehensive management platform will automatically generate a new subsidy, or the applicant will re-apply.

  V. Audit

  (a) the streets (towns) to accept applications through the comprehensive management platform, or on-site confirmation of the application materials, the information will be collected into the Beijing old-age care service subsidy management system of the comprehensive management platform; In principle, the department in charge of civil affairs will be transferred to the street (township) on the day of receiving, and it will be transferred from the system to the District Civil Affairs Bureau after preliminary examination. Before the 20th of each month, all the streets (towns) will submit the data of people who have objections to the District Civil Affairs Bureau.

  (two) the District Civil Affairs Bureau shall make an examination and approval opinion before the 25th of each month. If the examination and approval is unqualified, put forward opinions and inform the parties in writing through the street (township) acceptance window, explain the reasons, relief channels and time limit, and file the application materials electronically and keep them properly; Those who pass the examination and approval shall be reported to the District Finance Bureau for disbursement of funds.

  VI. Distribution

  Subsidies and allowances for old-age care services for the elderly are paid on a monthly basis. Those who pass the examination and approval will be paid in the month when they submit their applications, and subsidies and allowances will be paid next month before the end of each month.

  Since the date of implementation, if the application is delayed for more than half a year due to the applicant himself or other reasons, it will be counted from the month when the application is submitted. If the application time is delayed within 6 months, it shall be counted and distributed from the eligible month after the application is submitted according to regulations.

  All departments use the comprehensive management platform to complete business processes such as application acceptance and treatment approval. After capital accounting, they will transfer money to financial institutions through the civil administration funds unified supervision information platform and deposit it in the bank card financial account confirmed by the applicant at the time of application.

  When applying, the applicant can use one of the existing "Beijing Tong-Pension Card for the Disabled", "Beijing Tong-Civil Affairs Card", "Beijing Tong-Disabled Service Card", special family support card for the elderly, "Beijing Tong-Third Generation Social Security Card" and military security card as an account for the payment of pension service subsidies.

  Among them, the old-age allowance for the elderly aged 80-89 years old who hold the "Beijing Tong-Pension Card for the Disabled" as the payment account shall be implemented according to the original payment method and channel of home-based care service subsidies, and the nursing allowance shall not be withdrawn.

  VII. Review

  (a) the review of the old-age service subsidies for the elderly shall be regularly reviewed by the District Civil Affairs Bureau through the comprehensive management platform, at least once every quarter; Or by individuals to declare their own review.

  (II) Under any of the following circumstances, each street (township) or district civil affairs bureau will directly implement it from the next month when the subsidy conditions change according to the automatic early warning information of the comprehensive management platform, or after checking with the applicant/guardian, without the need for the applicant to provide materials:

  1. The disability category and disability level of the elderly have changed;

  2. The economic or family situation has changed, which does not meet the conditions for the elderly in special families with subsistence allowances, low income and family planning;

  3. The household registration moves out of this city;

  4. Dead or declared missing by the people’s court;

  5. Those who violate the law and commit crimes and are executing the imprisonment penalty;

  6. Those who fail to pass the review.

  If the subsidy fund is increased, decreased or stopped due to the change of the applicant’s personal situation, the comprehensive management platform will actively send information to the applicant to ensure the applicant’s right to know.

  Eight, household registration migration

  The transfer-out place will stop issuing subsidies for the elderly pension service from the month after the transfer formalities, and the transfer-in place will be issued from the month when the transfer-out place stops issuing (the integrated management platform will automatically push the transfer information to the applicant’s reserved mobile phone).

  IX. Financial Guarantee

  (a) the funds needed for the old-age service subsidies shall be included in the annual district-level budget arrangement by the financial burden of the district where the old-age household registration is located, and can actively attract social charity, donation funds and other support.

  (II) In order to alleviate the pressure of raising financial funds in each district, the Municipal Finance Bureau will give the municipal fixed special transfer payment support on an annual basis according to the data of the elderly population in each district released by the Municipal Bureau of Statistics, the Municipal Health and Health Commission and the Municipal Disabled Persons’ Federation in the previous year, in which the nursing allowance for the disabled elderly is 100 yuan per person per month, the old age allowance is 100 yuan, who is 80-89 years old, 200 yuan, who is 90-99 years old, and 300 yuan, who is over 100 years old. It is managed and used in accordance with the Notice of the Municipal Finance Bureau, the Civil Affairs Bureau, the Municipal Human Resources and Social Security Bureau, and the Municipal Disabled Persons’ Federation on Printing and Distributing the Administrative Measures for Special Transfer Payment Funds for Social Security and Employment in Beijing (J.C.S. [2018] No.323).

  (three) the city-wide standard and the city-to-district subsidy standard for the elderly pension service subsidies will be adjusted by the Civil Affairs Bureau in conjunction with relevant departments in a timely manner according to the changes in the economic and social development of this Municipality and the income level of residents.

  X. Management and Supervision

  (1) The Civil Affairs Bureau is responsible for establishing a unified working system and management information system for the elderly pension service subsidies, service management and disability assessment in the city, guiding all districts to carry out subsidies, organizing services and other related work, and taking the lead in promoting the working mechanism of interconnection and sharing of relevant information among government departments. The Municipal Finance Bureau is responsible for guiding all districts to do a good job in the budget and guarantee of subsidies for the elderly pension services. The Municipal Human Resources and Social Security Bureau is responsible for guiding the street (township) social security offices in the relevant areas to do a good job in accepting and transferring applications. The Municipal Health and Wellness Commission is responsible for the information services related to the elderly in family planning special families, as well as the maintenance and protection of the rights and interests of the elderly. The Municipal Bureau of Veterans Affairs is responsible for coordinating and coordinating the implementation of the relevant living security benefits for retired soldiers. The Municipal Medical Insurance Bureau is responsible for the pilot guidance and convergence of the long-term care insurance system. City Disabled Persons’ Federation is responsible for the examination, issuance, management and protection of the rights and interests of the disabled for the elderly to apply for disability certificates.

  (two) the Civil Affairs Bureau in conjunction with the relevant departments to co-ordinate and guide the policy propaganda work, and create a good atmosphere of public opinion. The civil affairs bureaus of all districts jointly deploy and implement the propaganda work in this district with relevant departments, and earnestly do a good job in policy notification; All streets (towns and villages) should adopt flexible and diverse forms to publicize and interpret the subsidy system for old-age care services, so that the elderly and their families can fully understand the policy content, application process and implementation norms.

  (three) the elderly pension service subsidies agencies should adhere to the principles of openness, fairness and impartiality, and strictly examine and handle them; Civil affairs departments at all levels shall manage and monitor the implementation of the subsidy system; Relevant departments and institutions should take the initiative to accept the inspection and social supervision of the financial and auditing departments.

  (4) If it is verified that there is graft or false report, false claim, false claim, interception, misappropriation, fraud or spamming of subsidy funds, the District Civil Affairs Bureau shall immediately carry out investigation, collect evidence, interview the parties concerned, and order them to return the subsidies that were wrongly claimed or falsely claimed. If the amount is large and suspected of committing a crime, it shall be transferred to judicial organs for handling according to law, and the administrative and legal responsibilities of the relevant personnel shall be investigated, and all the subsidy funds for "illegal income" shall be recovered.

  (5) Civil affairs, finance and other departments at all levels and their staff who distribute funds in violation of regulations, or distribute and distribute funds to unqualified units (or individuals), abuse their powers, neglect their duties, engage in malpractices for selfish ends in the whole process of the allocation, review, disbursement, use and supervision of funds for the elderly pension service subsidies shall be punished in accordance with the Budget Law, the Civil Service Law, the Supervision Law and the Financial Violations. Suspected of a crime, promptly transferred to judicial organs.

  XI. Supplementary Provisions

  (1) If there is any inconsistency with the provisions of these Measures, these Measures shall prevail.

  (two) after the implementation of these measures, Measures for the Payment of Allowances for the Elderly in Beijing (Jing Lao Ban Fa [2008] No.12), Measures for the Subsidy of Old-age Services for Special Elderly in Beijing (Trial) (Jing Min Fu Fa [2008] No.335), and Opinions on Implementing the "Nine-support Measures" for Home-based Care (Helping the Disabled) Services for Beijing Citizens (Jing Min Lao Fa [2008]) Notice on Implementing the Subsidized Medical Care System for the Elderly Aged 95 and Over (J.M.G.F. [2011] No.149), Measures for the Administration of Pension Card for the Disabled in Beijing (for Trial Implementation) (J.M.G.F. [2014] No.459) and Measures for the Administration of Pension Service Units for the Disabled in Beijing (for Trial Implementation) (J.M.G.F. [2014] No.460) Notice on related service matters in home care service for the elderly and disabled with financial difficulties (J.M.R.F. [2015] No.477), Measures for Evaluating the Ability of the Elderly in the Pilot Area of Home Care Service for the Elderly and Disabled with Financial Difficulties (J.M.R.F. [2015] No.478), Administrative Measures for Stopping and Recovering Home Care Service Subsidies in Beijing (J.M.R.F. [2016] Relevant documents, such as the Notice on Centralized Recovery of Subsidies for Home-based Care Services by Misleading or Taking the Initiative (J.M.G.F. [2016] No.357) and the Administrative Measures of Beijing Tong-Pension Card for the Disabled (for Trial Implementation) (J.M.G.F. [2016] No.431), shall be abolished.

  (three) the Municipal Civil Affairs Bureau is responsible for the specific interpretation of these measures.

  (4) These Measures shall come into force as of October 1, 2019, and the first subsidy funds shall be paid before the end of November.

  Attachment: 1. Application Form for Allowance for Old-age Services in Beijing (omitted)

     2 Beijing old-age service subsidies audit table (omitted)

     3 Beijing old-age care service subsidy transfer form (omitted)

     4. Summary table on the payment of subsidies for the aged care service for the elderly in Beijing (omitted)

     5. Summary table on the distribution of nursing subsidies for the disabled elderly in Beijing (omitted)

     6. Summary of the payment of old age allowance for the elderly in Beijing (omitted)

National Health Commission: Since the implementation of the national regional medical center construction project, more than 1,400 diagnosis and treatment technologies have been translated to the impo

  CCTV News:On April 13th, National Health Commission held a press conference on the expansion and sinking of high-quality medical resources and the balanced distribution of regions. Da-chuan Li, deputy director of the Department of Medical Administration of the National Health and Wellness Commission, introduced at the conference that since the 12th Five-Year Plan, the State Council has made the work arrangement of setting up "double centers" in nearly three health development and five-year plans of the medical and health system. At present, the establishment and construction of "Double Centers" have been written into the Law on Basic Medical Care and Health Promotion, the 14th Five-year Plan for National Economic and Social Development and the Outline of Long-term Goals in 2035, and included in the special "14th Five-Year Plan" issued by the State Council. Up to now, the National Health and Wellness Commission has set up 13 national medical centers in professional categories and national regional medical centers in children’s categories according to procedures. At the same time, the National Health and Wellness Commission and the National Development and Reform Commission approved 76 national regional medical center construction projects in four batches in areas with weak medical resources.

  After years of hard work, the National Medical Center and the National Regional Medical Center mobilized and aggregated local governments, universities, scientific research institutions and other forces, carried out in-depth core technology research, focused on solving long-term and overall medical problems affecting people’s health, and produced a number of groundbreaking clinical research results. In 2022 alone, the "Double Center" launched 372 international and domestic pioneering and leading technologies. Since the implementation of the national regional medical center construction project, more than 1,400 diagnosis and treatment technologies have been transferred to the imported provinces, filling the gaps in more than 300 provincial medical technologies, and the number of people seeking medical treatment in relevant provinces has dropped significantly.

Hu Manzhi created and shared with you the "messenger" of intercellular communication-cytokines.

The future of cytokine detection is bound to be a red sea. You should know about these clinical applications.

Foreword:

In our bodies, there is a mysterious and powerful system, which always protects us from external pathogens. This system is our immune system, which is composed of many immune cells, like a well-trained army, always ready to resist foreign enemies. In this army, there is a mysterious force playing a role silently, which is cytokine.

Overview of cytokines

Cytokines are a kind of small molecular protein with wide biological activity, which is synthesized and secreted by immune cells (such as monocytes, macrophages, T cells, B cells, NK cells, etc.) and some non-immune cells (such as endothelial cells, epidermal cells, fibroblasts, etc.), and is equivalent to the "messenger" of mutual communication among various cells in human body.

It has many biological functions, such as regulating cell growth, differentiation and maturation, maintaining function, regulating immune response, participating in inflammatory reaction, wound healing and tumor growth and decline.

At present, the detection of cytokines is widely used in infections, kidney diseases, autoimmune diseases, tumors and malignant hematological diseases, which has important clinical significance in the diagnosis of diseases, the judgment of treatment opportunity, the guidance of medication, the monitoring of curative effect, the early warning of cytokine storm risk and the improvement of patients’ treatment efficiency.

Classification and main functions of cytokines

According to their main functions, cytokines can be divided into the following categories: interleukin (ILs), colony stimulating factor (CSFs), interferon (IFNs), tumor necrosis factor (TNFs), growth factor (GFs) and chemokine (CK).

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There are both pro-inflammatory factors and anti-inflammatory factors. Pro-inflammatory factors usually regulate the growth, activation, differentiation and homing of immune cells to infected sites, aiming at controlling and eradicating intracellular pathogens (including viruses); Anti-inflammatory cytokines are a series of immunomodulatory molecules that control the response of pro-inflammatory cytokines.

In the development of infection, the interaction between pro-inflammatory factors and anti-inflammatory factors runs through, which has a far-reaching impact on the development direction and outcome of infection.

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Clinical application value of cytokines

1, early diagnosis of infection, conducive to disease monitoring.

Shortening the window period helps to realize early diagnosis and win valuable time for treatment; The half-life is short, which is convenient to monitor the efficacy in time and ensure the effectiveness and safety of treatment; Complement with PCT and CRP, improve the accuracy of diagnosis and provide strong support for precise treatment.

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Note: In the Expert Consensus on Interpretation of Clinical Significance of Infection-related Biomarkers published in 2017, IL-6 has been regarded as one of the infection-related biomarkers.

2, help to determine the type of infection.

A study showed that IL-6 and IL-10 increased more than 10 times at the same time, suggesting G- bacteria infection; IL-6 increased by 2 times, and IL-10 increased by less than 10 times, suggesting G+ bacteria infection. According to the cytokine spectrum, the effective rate of identifying Gram bacteria to guide antibiotic treatment is close to that of broad-spectrum coverage group, up to 85%, while the effective rate of empirical treatment group is only 60%.

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3. Early warning of cytokine storm

During the period of COVID-19, many critically ill patients suffered from uncontrolled release of cytokines such as IL-6, IL-8, TNF-α, IFN-γ, which led to coagulation storm, thrombosis, myocardial infarction and pulmonary embolism, leading to respiratory failure, organ failure and even death.

Although IL-6 is the key cytokine for everyone at present, it should not be the only one. Cytokines is a huge regulatory network, which is coordinated with each other, constantly changing dynamically and changing with the course of disease.

Therefore, it is suggested that patients at risk of cytokine storm should be jointly tested for cytokines during admission and hospitalization.

4. Assess the inflammation and immune status of the body.

Severe patients may have three inflammatory/immune states: SIRS (Systemic Inflammatory Response Syndrome), CARS (Antagonistic Inflammatory Response Syndrome) and MARS (Mixed Antagonistic Response Syndrome).

When infection or other reasons lead to the imbalance of inflammatory response, if the levels of a large number of proinflammatory factors such as IL-1β, IL-6, IL-8, IL-12, IFN-γ, IFN-α and TNF-α are greatly increased, there is a risk of systemic inflammatory response syndrome -SIRS, and the inflammatory response of the body is strong at this time, so it is recommended to give priority to anti-inflammatory treatment; If the endogenous anti-inflammatory reaction is too strong, the anti-inflammatory factors such as IL-4 and IL-10 will be greatly increased, which indicates the risk of CARS. At this time, the immune function of the body is weak, and it is suggested to strengthen the immune treatment. If both pro-inflammatory factors and anti-inflammatory factors increase significantly, it suggests that the body is a mixed antagonistic response syndrome, suggesting that the body has a strong inflammatory response and low immune function, and it is suggested to carry out anti-inflammatory combined with immune enhancement therapy.

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5. Cytokines and Tumor

Cytokines are the key proteins of signal transmission in tumor microenvironment (TME), which have pleiotropic effects. In terms of anti-tumor, interferon and TGF-β can directly inhibit the growth of tumor cells, while IFN-γ, IL-2, IL-12 and IL-15 can enhance the cytotoxic activity of lymphocytes or bone marrow cells, thus inhibiting cell growth; In promoting tumor, TGF-β, TNF, IL-1β, CXCL12, etc. can promote the survival and proliferation of tumor cells; TNF, IL-6, etc. can cause the disorder of cytokine regulation and promote the occurrence of tumor inflammation; IL-10, IL-4, TGF-β, etc. are immunosuppressed; TNF, IL-6 and various chemokines can also promote angiogenesis.

Studies have confirmed that IL-6, IL-10 and IL-12 are slightly increased, while IL-2, TNF-α and IFN-γ are significantly decreased, suggesting that there may be early tumor microenvironment progress. Early warning of the occurrence of adverse reaction cytokine release syndrome (CRS) caused by PD-1 therapy /CAR-T therapy.

6. Cytokines and Autoimmunity

Hemophagocytic syndrome (HLH):HLH may be caused by persistent antigen stimulation caused by autoimmune diseases or malignant tumors, with high mortality. IL-2R is one of the diagnostic criteria (from China Expert Consensus on Diagnosis and Treatment of Hemophagocytic Syndrome). In addition, the slight increase of IFN-γ, IL-10 and IL-6 can also distinguish HLH from infection, which is helpful for the treatment of HLH patients.

Systemic lupus erythematosus (SLE): As a chronic autoimmune disease, SLE will affect many organ systems, including but not limited to skin, joints and kidneys. Cytokines in active SLE patients, including IL-8, IL-18, IL-6 and IFN-α, were significantly higher than those in inactive SLE patients. Especially, IL-6 and IL-8 showed better sensitivity and specificity than traditional C3, C4 and Anti-dsDNA.

Henoch-Schonlein Purpura (HSP): A large number of studies show that inflammatory cytokines in HSP patients are out of balance, mainly IL-6, IL-8 and TNF-α. When the cutoff value of IL-6 is set to 7 pg/mL, the sensitivity and specificity can reach 78.0% and 80.5%. The change of IL-8 will be greater, which is 2-10 times of the baseline level of healthy people.

7, cytokines and asthma, allergic diseases and lung diseases.

Generally speaking, children’s allergic diseases such as asthma and allergic rhinitis are mainly mediated by humoral immunity (IgE-mediated type I allergy). IL-4 and IL-5 can promote the secretion of IgE antibodies, aggravate allergic diseases, monitor the levels of IL-4 and other proinflammatory factors, and evaluate the condition and efficacy.

In addition, pro-inflammatory cytokines such as IL-6, IL-8 and TNF-α can promote the progress of airway inflammation such as chronic obstructive pulmonary disease (COPD) and pneumonia, and evaluate the changes of cytokine levels, so as to evaluate the disease progress and drug efficacy monitoring of the above diseases.

8. Cytokines and Reproductive Medicine

Studies have proved that Th1 cytokines are significantly increased and Th2 cytokines are decreased in patients with unexplained recurrent abortion. It has also been reported in the literature that the significant increase of IL-22 concentration may be related to unexplained recurrent abortion.

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Advantages and disadvantages of mainstream detection methods for cytokine reagents

1, chemiluminescence method

Advantages: The method is mature and stable in technology, high in sensitivity and wide in linear range, and can efficiently complete single detection in a short time.

Disadvantages: it is impossible to carry out multi-project joint inspection and the sample demand is large, which makes it unable to cope with the large sample size test.

2. Flow fluorescence method

Advantages: As a relatively new detection method, flow fluorescence method stands out for its advantages of realizing multi-item joint inspection with small sample size, especially in large sample size testing, which saves time and cost.

Disadvantages: It may not be as sensitive as the light-emitting platform, and it is difficult to solve the interference problem that may be introduced in the process of multi-joint inspection, which affects the accuracy of its detection to some extent.

3. Enzyme-linked immunosorbent assay

Advantages: The method is mature and stable, with high sensitivity and good stability.

Disadvantages: the reaction time is relatively long, the linear range is narrow, and the detection efficiency is low, so it is more used in scientific research.

Market situation and current situation sharing of cytokine reagents

1. The domestic heat is higher than that of foreign countries.

Through investigation, we found that, for cytokine projects, except IL-6, foreign manufacturers are more respected, and almost no other manufacturers have obtained certificates in China or even CE. At present, only Siemens has obtained the registration certificates for six projects, namely IL-1β, IL-2R, IL-6, IL-8, IL-10 and TNF-α, in China, which is regarded as an early cytokine project company that entered the China market.

The joint inspection of cytokine combination project seems to be a unique project in China, and it is difficult for us to find similar packaged tests in other countries.

From the actual clinical point of view, COVID-19 and sepsis have confirmed the significance of IL-6 detection, and hemophagocytic syndrome has clarified the value of IL-2R detection. However, for other cytokine detection, although everyone is advocating the clinical significance of each index, there is no more recognized expert consensus to explain it. It can only be said that the market prospect is there, but more clinical practice is needed to confirm it.

At present, there are mainly two factions in the detection of cytokines in China, such as the magnetic particle light-emitting platform of Hot Scene Bio, which has obtained the registration certificates of 13 indicators, namely TNF-α, IFN-γ, IL-1β, IL-2, IL-2R, IL-4, IL-5, IL-6, IL-8, IL-10 and IL. At present, the flow fluorescence platform made by Hu Manzhi is generally combined with 12 items, namely TNF-α, IFN-α, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70 and IL-11.

2. Although there are international standards for each project, the testing situation of each manufacturer is not uniform.

Due to the lack of foreign reagents, it seems difficult to maintain the consistency of test results except IL-6. Although almost every project has international standards, from the data of clinical tests, the test results of various manufacturers deviate seriously, and it is difficult to judge which manufacturer’s test value is more accurate. It may be inferred that the traceability chain of each manufacturer is not particularly strict.

We know that most cytokines can’t be stored stably at room temperature, so the general calibrators are in the form of freeze-drying, which may be due to the loss during freeze-drying, or the interference of composite quality control such as flow platform, or the matrix effect introduced in the dilution process of international standards, which makes the test results of reagents difficult to be unified and leads to confusion in clinical judgment.

Market prospect of cytokine detection reagents

Although we have mentioned the problem that various cytokines form a complex network of communication and restriction between cells, there is no disease-specific guidance for many indicators at present, and it is difficult to unify the test results among manufacturers, but on the other hand, it is a huge opportunity for reagent manufacturers. Why do you say that?

First of all, the broad indications of detection indicators mean that cytokine items can be detected in various departments, with a large volume; Moreover, there are not many manufacturers in this testing field, and compared with conventional testing items, the homogenization is not serious and the market prospect is relatively broad; Moreover, the difference in the test results of manufacturers will inevitably lead to the emergence of benchmark enterprises in this field, so many enterprises can establish their own brand image through this product; It is believed that with the further implementation of the consensus of experts in various fields and the gradual maturity of emerging technologies such as flow fluorescence and single molecule detection, cytokine detection will surely be a red sea.

Today’s sharing is here, I hope it will inspire you. (For more information about cytokine detection reagents, please search the official website of HUMAN Zhizhi and click to inquire.)

About Hu manzhizao

Beijing Human Zhizao Technology Co., Ltd. is a medical technology innovation company integrating R&D, production and sales. With years of experience in materials science, in vitro diagnosis technology and marketing, based on the core of multi-flow fluorescence technology, the company is committed to providing fully automatic multi-flow fluorescence detection platform and supporting reagents with competitive advantages for clinical customers, and has built a "new ecology" for ultra-high-speed immunodiagnosis, focusing on major immune diseases, intractable diseases and rare diseases.

Heavy! The tenth edition of COVID-19 diagnosis and treatment plan adjustment points.

  Recently, the National Health and Wellness Commission and state administration of traditional chinese medicine organized the revision of the novel coronavirus Diagnosis and Treatment Plan (Trial Ninth Edition) and formed the novel coronavirus Infection Diagnosis and Treatment Plan (Trial Tenth Edition). The key revisions are as follows:

  The name of the disease has been adjusted.

  According to the "Overall Plan for Implementing" Class B and B Management "for novel coronavirus Infection by the Comprehensive Group of the State Council Joint Prevention and Control Mechanism, the name of the disease was changed from" novel coronavirus "Renamed "novel coronavirus Infection". With the continuous variation of Covid-19, the virulence of Omicron virus weakened after it became the main epidemic strain. The main symptoms of human infection were cough, fever, sore throat and so on, and only a few infected people would progress to pneumonia.

  No longer judge "suspected cases"

  With the increasing richness of diagnostic methods and the continuous improvement of diagnostic efficiency,At present, Covid-19 infection can be diagnosed promptly, quickly and accurately by nucleic acid and antigen detection.In most cases, there will be no cases where the epidemiological history and clinical manifestations are consistent with the characteristics of the disease, but the pathogen detection can not be clear for a long time.

  Increase the positive test of Covid-19 antigen as diagnostic criteria.

  Antigen detection has good detection sensitivity for infected people with high viral load.With the maturity of antigen detection technology and the improvement of detection accuracy, Covid-19 infected people, especially those with strong infectivity, can be diagnosed in time through antigen detection.Considering that most infected people are treated at home, the antigen detection operation is simple and convenient, which is convenient for infected people to carry out rapid self-detection.

  Further optimize "clinical typing"

  With the constant variation of the virus, especially since the epidemic of Omicron strain, the pathogenicity of the virus has been gradually weakened, and the characteristics of the disease have changed obviously. Most infected people have mild symptoms and the proportion of pneumonia has been greatly reduced.In order to better reflect the characteristics of the disease, the tenth edition of the plan adjusted the clinical classification, mainly according to the severity of the infected person’s illness, divided into "light, medium, heavy and critical", which is more in line with clinical practice.

  Cases are no longer required to be "centralized and isolated"

  With the implementation of Class B and B management measures, Covid-19 infected people can choose home treatment or medical institutions according to the needs of treatment, and all kinds of medical institutions can treat Covid-19 infected people.

  Further improved the treatment method.

  The anti-Covid-19 drugs that have been approved for marketing in China will be included in the new diagnosis and treatment plan to further enrich the antiviral treatment methods.

  Further improve the diagnostic criteria and early warning indicators for severe and critical cases, and scientifically and accurately judge severe cases of infection in Covid-19. At the same time,The elderly who have not been vaccinated in the whole process will be added to the high-risk group of severe diseases, and the monitoring of vital signs, especially the monitoring index of finger oxygen saturation after rest and activity, will be added to the early warning index of severe diseases..

  Further strengthening the concept of co-treatment of Covid-19’s infection and basic diseases, emphasizing the need to strengthen the monitoring of related indicators of infected people’s basic diseases and give corresponding treatment for basic diseases, which is more conducive to promoting patients’ comprehensive recovery.

  Further optimize the clinical manifestations and treatment-related contents of children’s cases, put forward the characteristics of children infected with Omicron strain in combination with clinical practice, and improved the early warning indicators of severe cases in children.It provides a treatment plan for special situations such as acute laryngitis and nervous system complications that may occur in children infected.

  Further improved the related content of Chinese medicine treatment.Strengthen the guidance of traditional Chinese medicine treatment for severe and critical cases, and increase the method of medication with symptoms, which is more suitable for clinical practice.On this basis, the Chinese medicine treatment plan for children’s cases is further improved, acupuncture treatment methods are added, and corresponding Chinese medicine treatment measures are provided in combination with the obvious cough of some patients in recovery period.

  Adjust the "discharge standard"

  The tenth version of the plan no longer requires the results of nucleic acid detection when the infected person leaves the hospital, but the clinician makes a comprehensive judgment based on the patient’s Covid-19 infection, diagnosis and treatment of basic diseases or other diseases, and health recovery.

  When the patient’s condition is obviously improved, his vital signs are stable, his body temperature is normal for more than 24 hours, lung imaging shows that acute exudative lesions are obviously improved, and he can be converted to oral medication, and there are no complications that need further treatment, he can consider leaving the hospital.

  Adjust the prevention and control of infection in medical institutions

  After the adjustment of the epidemic prevention and control policy, all medical institutions have the possibility to accept cases of Covid-19 infection. The tenth edition of the diagnosis and treatment plan has adjusted the relevant contents of infection prevention and control in medical institutions.

  Further implement the system of pre-examination and triage for outpatient and emergency departments and do a good job of patient diversion. At the same time, instruct patients and accompanying personnel to wear medical surgical masks or medical protective masks, and provide instructions on hand hygiene, respiratory hygiene and cough etiquette.

  Strengthen the cleaning, disinfection and ventilation of consultation rooms, wards, offices and duty rooms.

  Implement personal protection requirements of medical staff according to exposure risks.

  Standardize the treatment of medical waste and implement terminal disinfection after patients are transferred out or discharged from hospital.

  ▌ This article Source: CCTV News WeChat WeChat official account (ID: CCTV News Center)

  Producer/Editor-in-Chief Bing Xu/Ma Wenjia

  Headquarters reporter/Shi Yingchun

  Editor/Yu Zijing Drawing/Gao Mengru

  Image source/vision china

Five practical skills of Huawei Pura70 are shared, and new users should try it quickly.

Huawei Pura70 series has been released for many days, and I believe many small partners have already touched it.

I’ve seen a lot of introductions of new functions and new hardware these days. I wonder if you pay attention to the changes in experience. Huawei Pura70 series is equipped with the latest HarmonyOS 4.2, and there are still many changes in details. For many new users, if you don’t study it in depth, you may regret missing it. Then take stock of a few more interesting functions, take a new machine in hand, or plan to start a new machine, you can take a look.

1. "Shake" to intercept jump advertisements

I don’t know which product manager invented the "shake" jump advertisement, but I guess his performance must be very good.

In any case, it is necessary for the mobile phone to stop the "shake" advertisement. After all, it is really useful.

I am deeply touched by this point. During the Double Eleven last year, I still used it. It didn’t have the advertisement interception function. As a result, some apps were opened at one point, and the first thing I jumped to was the shopping platform, which was annoying. It was changed at the beginning of the year. Starting from the latest surge, this mobile phone supports "getting device movements and directions" on and off, and the experience has also been qualitatively improved.

With the release of Huawei Pura70 series, Huawei users can also set the "Application acquisition device direction" for the app in this mobile phone. Personally, this function is not bad, and new users can turn it on or off as needed. Of course, if it is set to prohibit, in addition to shaking the advertisement jump, the game control and automatic screen flipping may also be affected, which needs attention.

2, photo AI elimination

With the explosion of the concept of "AI big model", some useful AIGC functions have been widely used, such as image elimination.

At present, mainstream flagship mobile phones such as Huawei, Glory, OPPO, vivo and Xiaomi all support the AI ? ? picture elimination function, and their performance is naturally mixed.

The image elimination function of Huawei Pura70 series is good in some scenes, and the overall evaluation can be given to the upper-middle. I believe it will be better with the optimization of subsequent systems and the improvement of large model capabilities.

3. Smart screen recognition

Smart screen recognition is a super easy-to-use function, but 99% of consumers actually don’t care.

For example, if you want to recognize the words on the picture, cut out some words, logos or photos, or translate between Chinese and English, compare prices of goods, etc., in the past, you needed a three-party App, or manually search for some more complicated menu operations. If you use smart screen to operate, it will be very convenient and fast.

On Huawei Pura70 series, users only need to hold down the screen with two fingers at the same time, which can trigger the intelligent screen recognition function, which can be carried out in any interface, including the operation of coding chat records with one button.

4. Artistic protagonist

The artistic protagonist is a custom theme function, and users can set their own photos as themes. The difference is that this function supports powerful customization. When you set a photo, the system will automatically matting the portrait, and users can also adjust the image at will.

In addition, the artistic protagonist has a wealth of texture styles and colors to choose from to meet the personalized needs.

5. Interactive theme

It also belongs to the category of theme customization. Unlike traditional static themes or dynamic themes, Huawei Pura70 series provides several themes that can interact with users. In addition to supporting sticker customization, it can also interact with users. For example, when users light up the screen, the wallpaper will move, and when the screen is turned off, the wallpaper will also move; Every time you slide into the desktop, the sticker will show a different animation form. Even when you click on the sticker with your finger, it will respond accordingly, which not only fills up the visual effect, but also makes every operation more interesting.

That’s all about the sharing of new functions of Huawei Pura70 series. Don’t forget to give it a try for new users. They are all very interesting and practical functions, which I believe will bring you a different experience.

China FAW Yancheng Branch put into production, the first model Pentium pony was officially mass-produced.

On May 17th, China FAW Yancheng Branch was put into production and the first car mass production ceremony was officially held. Pentium pony, the first model born in the new factory, was mass-produced and shipped to its dealers all over the country. With the mass production of the first car, the new energy factory of China FAW Yancheng Branch was officially unveiled for the first time, which opened the Pentium brand of China FAW and accelerated the development of new energy industry layout.

Relevant responsible persons from Yancheng Municipal Party Committee and Municipal Government, China FAW, FAW Pentium, Yancheng Economic and Technological Development Zone and Jiangsu yueda Group came to the scene to witness this important moment. The main responsible comrades of Yancheng Municipal Party Committee and Municipal Government, Wang Guoqiang, director and deputy secretary of the Party Committee of China FAW Group Co., Ltd., Yang Chang, chairman and secretary of the Party Committee of FAW Pentium Automobile Co., Ltd., and Kong Dejun, general manager and deputy secretary of the Party Committee of FAW Pentium Automobile Co., Ltd. jointly launched the commissioning and first car mass production ceremony of China FAW Yancheng Branch.

Wang Guoqiang said in his speech that as an important part of the strategic layout of China FAW’s new energy industrial chain, the commissioning of China FAW Yancheng Base greatly supplemented the production capacity layout of China FAW’s independent new energy vehicles, marking a key step in the strategic layout of China FAW’s new energy. As the first new energy strategic model of Pentium brand, Pentium Pony will further enhance the competitiveness and influence of Pentium in the new energy market, and bring more scene and personalized car experience to consumers.

As a new energy passenger car production base established by China FAW, Yancheng Branch will undertake the production tasks of various new energy main models of Pentium brand in the future, which will become an important guarantee to support the development of China FAW’s own brand and promote the transformation of FAW Pentium’s new energy. With the accelerated transformation, FAW Pentium will launch seven new energy vehicles, covering pure electric, plug-in hybrid, extended range power and other types of products.

Pentium pony is the first product of FAW Pentium’s new energy transformation, which will be officially launched on May 28th. Since the pre-sale, it has become the new "budding master" of the micro pure electric travel market with the five good experiences of "good-looking, fun, easy to open, economical and safe".

In addition, the brand-new new energy vehicle of Pentium brand, code-named E311, also made its debut at the event. This vehicle is an all-electric SUV with high price-performance ratio and high quality-price ratio, which will bring consumers a brand-new travel experience with cutting-edge technology.

The commissioning of China FAW Yancheng Branch will bring sufficient capacity support and quality assurance for the planning and landing of new energy products of FAW Pentium. By the end of this year, China FAW Yancheng Branch will invest and transform 30 production lines one after another, reaching the annual output of 100,000 vehicles, and the production capacity will exceed 150,000 vehicles by the end of 2025, making it an intelligent, green and efficient modern manufacturing enterprise. In terms of manufacturing quality, it can realize 100% automation, high precision and zero error in body welding, and 100% data upload in final assembly can realize traceability of vehicle quality. In terms of quality inspection, the laser radar with a measurement accuracy finer than the hair ensures the uniform and beautiful gap between vehicles, and the detection intensity of rain around 360 degrees reaches more than twice the national standard. Through more than 16 kinds of complex road conditions tests, 19 rigorous tests in 4 categories are carried out in the whole process, which reflects the quality standards of China FAW.

From the official mass production of Pentium pony to the surprise appearance of E311, and then to the high standard landing of Yancheng New Energy Factory, FAW Pentium has entered a new round of strategic transformation. Relying on more than 70 years’ accumulation of China FAW and Yancheng’s complete industrial supporting facilities, FAW Pentium will reinforce its advantages in the Yangtze River Delta market, which is the core of new energy vehicle consumption, showing a new pattern of coordinated layout of North-South bases and common development of North-South markets.

Be alert! These bacteria may cause diseases such as sepsis and meningitis.

  In summer, the weather is hot, and the growth and reproduction of bacteria are increasingly active. The so-called "illness from the mouth", when cooking dishes, do you think that there may be "dangerous elements" hidden in the kitchen? What diseases will they cause?

  What are the common pathogens in the kitchen?

  1. Escherichia coli

  ● Can cause diseases: sepsis, infective endocarditis, liver abscess, peritonitis, pelvic inflammatory disease and urinary system infection.

  ● Symptoms after infection: abdominal pain, diarrhea, fever, nausea, dizziness, vomiting and shock.

  E. coli is harmless to human body under normal circumstances, but it is easy to cause disease once it is overdosed and human immunity is weak.

  ● E.coli has low requirements for living conditions, and it will grow in the kitchen where there is a little water or food residue, such as chopping boards, rags and sinks that have not been dried. It is warm and humid in summer, and the growth and reproduction of Escherichia coli is very fast.

  ● Escherichia coli is not resistant to high temperature. Generally, it can be killed in plain areas by boiling at 100℃ for about 15 minutes to 30 minutes. When the temperature is about 4℃, the growth rate of Escherichia coli slows down; When the temperature is below MINUS 20℃, it enters a dormant state and stops breeding.

  2. Listeria

  ● Can cause diseases: fetal arrest, abortion, meningitis.

  ● Symptoms after infection: abdominal pain, diarrhea, fever, nausea, dizziness, vomiting and shock.

  Listeria is known as the "refrigerator killer" and can still grow at 4℃. Milk, yogurt, eggs, meat, cold drinks and vegetables in the refrigerator may be parasitic.

  Low high temperature environment is easy to kill Listeria, and refrigerated food can be sterilized by boiling and heating. In addition, regular cleaning and disinfection of the refrigerator will help to eliminate Listeria.

  3. Vibrio parahaemolyticus

  ● Can cause diseases: gastroenteritis, acute renal failure and wound infection.

  ● Post-infection symptoms: severe abdominal pain, diarrhea, fever, nausea, dizziness, vomiting and shock may occur.

  ● Vibrio parahaemolyticus mainly lives in seafood such as fish, shrimp, crab, shellfish and seaweed. Eating food containing this bacterium or being scratched by food containing this bacterium can cause infection.

  ● Vibrio parahaemolyticus can be killed by heating at high temperature. If sterilized with boiling water, it is recommended to boil for more than 15 minutes.

  4. Salmonella

  ● Can cause diseases: bacteremia, septicemia, gastroenteritis, osteomyelitis, meningitis, vascular implant infection and bone and joint infection.

  ● Post-infection symptoms: persistent high fever, abdominal pain, diarrhea, nausea, dizziness, vomiting and shock may occur.

  Salmonella is easy to appear in kitchen knives, chopping boards, vegetables, fruits, eggs, chicken legs and other foods.

  Salmonella can be killed by heating at high temperature.

  5. Staphylococcus aureus

  ● Can cause diseases: meningitis, otitis media, septicemia, pneumonia, folliculitis, wound infection and paronychia.

  ● Post-infection symptoms: skin pustules, abdominal pain, diarrhea, fever, vomiting, dizziness, etc.

  ● It is often parasitic on human and animal skin, nasal cavity, throat, stomach and other tissues, and is also found in air and sewage. When eating food contaminated by the bacteria, or when the body wound comes into contact with pollution sources, it can cause infection.

  Staphylococcus aureus has a certain tolerance to high temperature, and it can be killed in a high temperature environment above 80℃ for 30 minutes. 70% ethanol can also be used for disinfection.

  The doctor reminded that the symptoms caused by these pathogenic bacteria when invading the human body have many similarities, such as diarrhea, abdominal pain, fever, etc. Therefore, once an infection occurs, it is necessary to go to the hospital for examination and test to accurately identify which kind of bacteria is caused, and then take medicine for the symptoms.

  Transferred from CCTV Finance

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